Severe and Chronic Pain

Endocannabinoids: A unique opportunity to develop multitarget analgesics

Initial experiences with medicinal extracts of cannabis for chronic pain: results from 34 ‘N of 1’ studies.

Notcutt W. Price M, et al.
Anesthesia 2004;59:440-52.

Analgesic effect of the synthetic cannabinoid CT-3 on chronic neuropathic pain: a randomized controlled trial.

Karst M, Salim K, Burstein S, et al.
JAMA 2003;290:1757-62.

A preliminary controlled study to determine whether whole-plant cannabis extracts can improve intractable neurogenic symptoms.

Wade DT, Robson P, House H, et al.
Clin Rehabil 2003;17:18-26.

Efficacy of two cannabis based medicinal extracts for relief of central neuropathic pain from brachial plexus avulsion: results of a randomized controlled trial.

Berman JS, Symonds C, Birch R.
Pain 2004; 112:299-306.

Sativex successfully treats neuropathic pain characterized by allodynia: a randomized, double blind, placebo-controlled clinical trial.

Nurmikko TJ, Serpell MG, Hoggart B, et al.
Pain 2007; 133:210-20.

Cannabis and Pain